Non-vitamin-Koral anticoagulants and laboratory testing: Now and in the future: Views from a workshop at the European Medicines Agency (EMA)

Tomas Salmonson, Jean Michel Dogne, Heidi Janssen, Juan Garcia Burgos, Paul Blake

Research output: Contribution to journalReview articlepeer-review

Abstract

In contrast to Vitamin K antagonists, no routine coagulation monitoring is required in patients taking non-vitamin-K oral anticoagulants (NOACs). However, dosing must take into account factors such as patient age, renal function, and accompanying haemorrhagic risk. There has been considerable debate about when laboratory measurement might be appropriate and which tests should be used. A workshop at the European Medicines Agency recently discussed the evidence about laboratory measurement from formal studies, clinical experience, and the multiple perspectives on NOAC treatment, and considered how our knowledge might be further enhanced.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalEuropean Heart Journal - Cardiovascular Pharmacotherapy
Volume3
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Anticoagulation
  • Coagulation tests
  • Direct Oral Anticoagulants
  • DOACs
  • NOACs
  • Non-vitamin-K oral anticoagulants
  • Administration, Oral
  • Europe
  • Humans
  • Cardiology/education
  • Blood Coagulation/drug effects
  • Anticoagulants/administration & dosage
  • Societies, Medical
  • Education, Medical
  • Stroke/blood

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