NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Constant Gillot; Julien Favresse; François Mullier; Thomas Lecompte; Jean-Michel Dogné; Jonathan Douxfils

doi:10.3389/fphar.2021.708302

NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Constant Gillot, Julien Favresse, François Mullier, Thomas Lecompte, Jean-Michel Dogné, Jonathan Douxfils

Research output: Contribution to journal › Review article › peer-review

Abstract

NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

Original language	English
Article number	708302
Pages (from-to)	708302
Journal	Frontiers in Pharmacology
Volume	12
DOIs	https://doi.org/10.3389/fphar.2021.708302
Publication status	Published - 5 Aug 2021

Keywords

COVID-19
inflammation
NETosis
SARS-CoV-2
therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fphar.2021.708302

Cite this

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title = "NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments",

abstract = "NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.",

keywords = "COVID-19, inflammation, NETosis, SARS-CoV-2, therapeutics",

author = "Constant Gillot and Julien Favresse and Fran{\c c}ois Mullier and Thomas Lecompte and Jean-Michel Dogn{\'e} and Jonathan Douxfils",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Gillot, Favresse, Mullier, Lecompte, Dogn{\'e} and Douxfils.",

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doi = "10.3389/fphar.2021.708302",

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T1 - NETosis and the Immune System in COVID-19

T2 - Mechanisms and Potential Treatments

AU - Gillot, Constant

AU - Favresse, Julien

AU - Mullier, François

AU - Lecompte, Thomas

AU - Dogné, Jean-Michel

AU - Douxfils, Jonathan

PY - 2021/8/5

Y1 - 2021/8/5

N2 - NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

AB - NETosis is a form of neutrophil death leading to the release of extracellular chromatin and the assembling of proteins, including antiviral proteins, primed by an initial pathogenic stimulus. Under certain specific conditions, neutrophils can exhibit a double-edged activity. This event has been implicated in COVID-19 among other conditions. Neutrophil extracellular traps (NETs) are involved in the pathogenesis of COVID-19 by promoting a pro-inflammatory and a procoagulant state leading to multiorgan failure. This particular form of host defense promoted by neutrophils is closely related to the well-known cytokine storm observed in severe COVID-19 patients. These two elements therefore represent possible targets for treatment of severe SARS-CoV-2 infections.

KW - COVID-19

KW - inflammation

KW - NETosis

KW - SARS-CoV-2

KW - therapeutics

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U2 - 10.3389/fphar.2021.708302

DO - 10.3389/fphar.2021.708302

M3 - Review article

C2 - 34421600

SN - 1663-9812

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SP - 708302

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

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ER -

NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Abstract

Keywords

UN SDGs

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The COVILAB project : Clinical laboratory investigations related to COVID-19

Cite this

NETosis and the Immune System in COVID-19: Mechanisms and Potential Treatments

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

The COVILAB project : Clinical laboratory investigations related to COVID-19

Cite this