N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux; Jean-Michel Dogné; Bernadette Norberg; François Durant; Bernard Masereel

N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Catherine Michaux, Jean-Michel Dogné, Bernadette Norberg, François Durant, Bernard Masereel

Research output: Contribution to journal › Article › peer-review

Abstract

The title compound (BM531), C(17)H(26)N(4)O(5)S, has been designed for use as both a thromboxane synthase inhibitor (TXSI) and a thromboxane receptor antagonist (TXRA). We report here the X-ray crystal structure determination of the compound.

Original language	English
Pages (from-to)	621-623
Number of pages	3
Journal	Acta crystallographica. Section C: Crystal structure communications
Volume	58
Publication status	Published - Oct 2002

Keywords

Crystallography, X-Ray
Enzyme Inhibitors
Models, Molecular
Molecular Conformation
Molecular Structure
Receptors, Thromboxane
Sulfonylurea Compounds
Thromboxane-A Synthase

Cite this

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title = "N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition",

abstract = "The title compound (BM531), C(17)H(26)N(4)O(5)S, has been designed for use as both a thromboxane synthase inhibitor (TXSI) and a thromboxane receptor antagonist (TXRA). We report here the X-ray crystal structure determination of the compound.",

keywords = "Crystallography, X-Ray, Enzyme Inhibitors, Models, Molecular, Molecular Conformation, Molecular Structure, Receptors, Thromboxane, Sulfonylurea Compounds, Thromboxane-A Synthase",

author = "Catherine Michaux and Jean-Michel Dogn{\'e} and Bernadette Norberg and Fran{\c c}ois Durant and Bernard Masereel",

note = "Publication code : **RES. ACAD.",

year = "2002",

month = oct,

language = "English",

volume = "58",

pages = "621--623",

journal = "Acta crystallographica. Section C: Crystal structure communications",

issn = "0108-2701",

publisher = "Munksgaard",

}

N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition. / Michaux, Catherine ; Dogné, Jean-Michel ; Norberg, Bernadette et al.
In: Acta crystallographica. Section C: Crystal structure communications, Vol. 58, 10.2002, p. 621-623.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

AU - Michaux, Catherine

AU - Dogné, Jean-Michel

AU - Norberg, Bernadette

AU - Durant, François

AU - Masereel, Bernard

N1 - Publication code : **RES. ACAD.

PY - 2002/10

Y1 - 2002/10

N2 - The title compound (BM531), C(17)H(26)N(4)O(5)S, has been designed for use as both a thromboxane synthase inhibitor (TXSI) and a thromboxane receptor antagonist (TXRA). We report here the X-ray crystal structure determination of the compound.

AB - The title compound (BM531), C(17)H(26)N(4)O(5)S, has been designed for use as both a thromboxane synthase inhibitor (TXSI) and a thromboxane receptor antagonist (TXRA). We report here the X-ray crystal structure determination of the compound.

KW - Crystallography, X-Ray

KW - Enzyme Inhibitors

KW - Models, Molecular

KW - Molecular Conformation

KW - Molecular Structure

KW - Receptors, Thromboxane

KW - Sulfonylurea Compounds

KW - Thromboxane-A Synthase

M3 - Article

C2 - 12359948

SN - 0108-2701

VL - 58

SP - 621

EP - 623

JO - Acta crystallographica. Section C: Crystal structure communications

JF - Acta crystallographica. Section C: Crystal structure communications

ER -

N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Abstract

Keywords

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