MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine

Zhaokui Jin, Yanyuan Wen, Yaxin Hu, Wenwen Chen, Xianfeng Zheng, Weisheng Guo, Tianfu Wang, Zhiyong Qian, Bao Lian Su, Qianjun He

Research output: Contribution to journalArticlepeer-review


Nitric oxide (NO) has been well identified as a specific free radical molecule possessing wide-ranging therapeutic effects. Targeted delivery and controlled release of NO are highly desired to realize precision gas therapy, but are still challenging owing to the non-targetability and uncontrollability of NO itself. Herein, we propose a new concept of MRI-guided and ultrasound-triggered gas release for precision gas therapy. Based on this concept, we develop a novel ultrasound-responsive BNN-type NO-releasing molecule (NORM) and an advanced rattle-type nano-carrier of superparamagnetic iron oxide-encapsulated mesoporous silica nanoparticles (SPION@hMSN), and use them to construct a new intelligent nanomedicine (BNN6-SPION@hMSN) for the first time. The BNN6-SPION@hMSN nanomedicine exhibits excellent passive tumor-targeting capability, high MRI-guided tumor localization performance and a unique ultrasound-triggered NO release profile. The tumor-targeted, MRI-guided and ultrasound-triggered release profiles of the developed nanomedicine enable the tumor site-specific controlled release of NO in favor of high-efficacy and safe NO gas therapy of tumor.

Original languageEnglish
Pages (from-to)3637-3645
Number of pages9
Issue number10
Publication statusPublished - 14 Mar 2017
Externally publishedYes


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