Monte-Carlo dosimetry simulations of mono- and bi-isotopic radioactive sources used in prostate brachytherapy

Research output: Contribution to journalLiterature review

Abstract

Brachytherapy designs of sources have evolved during the past ten years. However, besides the type of radio-isotope (Pd-103, I-125 and recently Cs-131), no fundamental innovation have been proposed. The present work proposes an original seed loaded with two different isotopes in order to take the advantages of both. Theoretical dosimetry studies by Monte Carlo simulations have been performed to study the dose distribution of a combination of Pd-103 and I-125 in an InterSource-TM seed. It demonstrates advantages in comparison to mono-isotopic sources. Adjusting the relative activity of Pd-103 and I-125, one can get a higher dose at short distance avoiding Pd-103 cold spot and a smaller dose at long distances avoiding I-125 morbidity.
Original languageEnglish
Pages (from-to)553-556
Number of pages4
Journal5th International Conference on Isotopes
Publication statusPublished - 2005

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dosimeters
dosage
seeds
isotopes
simulation
adjusting

Keywords

  • Brachytherapy
  • Multiple radionuclide source
  • Iodine
  • Palladium

Cite this

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title = "Monte-Carlo dosimetry simulations of mono- and bi-isotopic radioactive sources used in prostate brachytherapy",
abstract = "Brachytherapy designs of sources have evolved during the past ten years. However, besides the type of radio-isotope (Pd-103, I-125 and recently Cs-131), no fundamental innovation have been proposed. The present work proposes an original seed loaded with two different isotopes in order to take the advantages of both. Theoretical dosimetry studies by Monte Carlo simulations have been performed to study the dose distribution of a combination of Pd-103 and I-125 in an InterSource-TM seed. It demonstrates advantages in comparison to mono-isotopic sources. Adjusting the relative activity of Pd-103 and I-125, one can get a higher dose at short distance avoiding Pd-103 cold spot and a smaller dose at long distances avoiding I-125 morbidity.",
keywords = "Brachytherapy, Multiple radionuclide source, Iodine, Palladium",
author = "Vincent Nuttens and Stephane Lucas",
year = "2005",
language = "English",
pages = "553--556",
journal = "5th International Conference on Isotopes",

}

TY - JOUR

T1 - Monte-Carlo dosimetry simulations of mono- and bi-isotopic radioactive sources used in prostate brachytherapy

AU - Nuttens, Vincent

AU - Lucas, Stephane

PY - 2005

Y1 - 2005

N2 - Brachytherapy designs of sources have evolved during the past ten years. However, besides the type of radio-isotope (Pd-103, I-125 and recently Cs-131), no fundamental innovation have been proposed. The present work proposes an original seed loaded with two different isotopes in order to take the advantages of both. Theoretical dosimetry studies by Monte Carlo simulations have been performed to study the dose distribution of a combination of Pd-103 and I-125 in an InterSource-TM seed. It demonstrates advantages in comparison to mono-isotopic sources. Adjusting the relative activity of Pd-103 and I-125, one can get a higher dose at short distance avoiding Pd-103 cold spot and a smaller dose at long distances avoiding I-125 morbidity.

AB - Brachytherapy designs of sources have evolved during the past ten years. However, besides the type of radio-isotope (Pd-103, I-125 and recently Cs-131), no fundamental innovation have been proposed. The present work proposes an original seed loaded with two different isotopes in order to take the advantages of both. Theoretical dosimetry studies by Monte Carlo simulations have been performed to study the dose distribution of a combination of Pd-103 and I-125 in an InterSource-TM seed. It demonstrates advantages in comparison to mono-isotopic sources. Adjusting the relative activity of Pd-103 and I-125, one can get a higher dose at short distance avoiding Pd-103 cold spot and a smaller dose at long distances avoiding I-125 morbidity.

KW - Brachytherapy

KW - Multiple radionuclide source

KW - Iodine

KW - Palladium

M3 - Literature review

SP - 553

EP - 556

JO - 5th International Conference on Isotopes

JF - 5th International Conference on Isotopes

ER -