TY - JOUR
T1 - Molecular recognition of nucleotides in water by scorpiand-type receptors based on nucleobase discrimination
AU - Inclán, Mario
AU - Albelda, M. Teresa
AU - Carbonell Llopis, Esther
AU - Blasco, Salvador
AU - Bauzá, Antonio
AU - Frontera, Antonio
AU - García-España, Enrique
PY - 2014/3/24
Y1 - 2014/3/24
N2 - The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP).
AB - The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP).
KW - molecular recognition
KW - nucleotides
KW - scorpiands
KW - sensors
KW - supramolecular chemistry
UR - http://www.scopus.com/inward/record.url?scp=84925285543&partnerID=8YFLogxK
U2 - 10.1002/chem.201303861
DO - 10.1002/chem.201303861
M3 - Article
C2 - 24574302
AN - SCOPUS:84896405394
SN - 0947-6539
VL - 20
SP - 3730
EP - 3741
JO - Chemistry: A European Journal
JF - Chemistry: A European Journal
IS - 13
ER -