Molecular recognition of nucleotides in water by scorpiand-type receptors based on nucleobase discrimination

Mario Inclán; M. Teresa Albelda; Esther Carbonell Llopis; Salvador Blasco; Antonio Bauzá; Antonio Frontera; Enrique García-España

doi:10.1002/chem.201303861

Molecular recognition of nucleotides in water by scorpiand-type receptors based on nucleobase discrimination

Mario Inclán, M. Teresa Albelda, Esther Carbonell Llopis, Salvador Blasco, Antonio Bauzá, Antonio Frontera, Enrique García-España

Research output: Contribution to journal › Article › peer-review

Abstract

The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP).

Original language	English
Pages (from-to)	3730-3741
Number of pages	12
Journal	Chemistry: A European Journal
Volume	20
Issue number	13
DOIs	https://doi.org/10.1002/chem.201303861
Publication status	Published - 24 Mar 2014

Keywords

molecular recognition
nucleotides
scorpiands
sensors
supramolecular chemistry

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10.1002/chem.201303861

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abstract = "The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP). ",

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AU - Inclán, Mario

AU - Albelda, M. Teresa

AU - Carbonell Llopis, Esther

AU - Blasco, Salvador

AU - Bauzá, Antonio

AU - Frontera, Antonio

AU - García-España, Enrique

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AB - The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP).

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Molecular recognition of nucleotides in water by scorpiand-type receptors based on nucleobase discrimination

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