TY - JOUR
T1 - Molecular lipophilicity potential by clip, a reliable tool for the description of the 3d distribution of lipophilicity
T2 - Application to 3- phenyloxazolidin-2-one, a prototype series of reversible MAO(A) inhibitors
AU - Ooms, F.
AU - Wouters, J.
AU - Collin, Sonia
AU - Durant, F.
AU - Jegham, S.
AU - George, P.
PY - 1998/6/2
Y1 - 1998/6/2
N2 - The capacity factor of eleven derivatives belonging to a prototype series of 3-phenyloxazolidin-2-one, reversible MAO inhibitors, was measured and compared to the calculated log P(calc) using the CLIP package. We demonstrate that this Molecular Lipophilicity Potential (MLP) approach is a valuable tool to estimate log P(calc) of such compounds.
AB - The capacity factor of eleven derivatives belonging to a prototype series of 3-phenyloxazolidin-2-one, reversible MAO inhibitors, was measured and compared to the calculated log P(calc) using the CLIP package. We demonstrate that this Molecular Lipophilicity Potential (MLP) approach is a valuable tool to estimate log P(calc) of such compounds.
UR - http://www.scopus.com/inward/record.url?scp=0032474519&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00230-3
DO - 10.1016/S0960-894X(98)00230-3
M3 - Article
C2 - 9871778
AN - SCOPUS:0032474519
SN - 0960-894X
VL - 8
SP - 1425
EP - 1430
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 11
ER -