Molecular interaction between reversible MAO-A inhibitors and the enzyme: Application to aryloxazolidinone, a prototype series

F. Ooms, S. Jegham, P. George, F. Durant, J. Wouters

Research output: Contribution to journalArticlepeer-review

Abstract

Among the various chemical classes of monoamine oxidase A inhibitors, phenyloxazolidinone represent one of the major series. The purpose of this paper is to review the experimental (X-ray diffraction, NMR, electronic absorption spectroscopy, lipophilicity studies) and theoretical (quantum chemistry, molecular mechanics, molecular dynamics) studies which have led to the description of the mode of interaction between phenyloxazolidinone inhibitors and the MAO-A enzyme.

Original languageEnglish
Pages (from-to)81-98
Number of pages18
JournalNeurobiology
Volume8
Issue number1
Publication statusPublished - 26 Sep 2000

Keywords

  • MAO-A
  • Molecular modelling
  • Phenyloxazolidinone
  • Reversible inhibitors
  • Review

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