Modulation of the arachidonic cascade with ω3 fatty acids or analogues: Potential therapeutic benefits

Isabelle Roland, Xavier de Leval, Brigitte Evrard, Bernard Pirotte, Jean Michel Dogné, Luc Delattre

Research output: Contribution to journalShort surveypeer-review

Abstract

Increasing interest in the role of ω3 fatty acids has arisen in these latest years since evidence of their implication in the cardioprotective fish based diet of the Inuit has been demonstrated. Furthermore, several in vitro, in vivo and epidemiological studies support the benefit of this fatty acids intake in various pathological states such as in the cardiovascular, cancer, inflammation, psychiatric, paediatric, pulmonary, dermatological and ophthalmologic fields. This review will focus on metabolism and pharmacological implication of ω3 fatty acids intake as well as its interest in the prevention or treatment of the above-mentioned pathologies.

Original languageEnglish
Pages (from-to)659-668
Number of pages10
JournalMini-reviews in medicinal chemistry
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • Cancer
  • Cardiovascular disease
  • Inflammation
  • Psychiatric disorders
  • ω3 fatty acid
  • ω6/ω3 ratio

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