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Abstract

Eukaryotic cells developed strategies to detect and eradicate infections. The innate immune system, which is the first line of defence against invading pathogens, relies on the recognition of molecular patterns conserved among pathogens. Pathogen associated molecular pattern binding to pattern recognition receptor triggers the activation of several signalling pathways leading to the establishment of a pro-inflammatory state required to control the infection.In addition, pathogens evolved to subvert those responses (with passive and active strategies) allowing their entry and persistence in the host cells and tissues. Indeed, several bacteria actively manipulate immune system or interfere with the cell fate for their own benefit. One can imagine that bacterial effectors can potentially manipulate every single organelle in the cell. However, the multiple functions fulfilled by mitochondria especially their involvement in the regulation of innate immune response, make mitochondria a target of choice for bacterial pathogens as they are not only a key component of the central metabolism through ATP production and synthesis of various biomolecules but they also take part to cell signalling through ROS production and control of calcium homeostasis as well as the control of cell survival/programmed cell death. Furthermore, considering that mitochondria derived from an ancestral bacterial endosymbiosis, it is not surprising that a special connection does exist between this organelle and bacteria. In this review, we will discuss different mitochondrial functions that are affected during bacterial infection as well as different strategies developed by bacterial pathogens to subvert functions related to calcium homeostasis, maintenance of redox status and mitochondrial morphology.

Original languageEnglish
Pages (from-to)173-185
Number of pages13
JournalBiochemical Pharmacology
Volume94
Issue number3
Early online date20 Feb 2015
DOIs
Publication statusPublished - 1 Apr 2015

Keywords

  • Bacteria
  • Calcium
  • Immunity
  • Metabolism
  • Mitochondria
  • MtROS

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  • Projects

    Equipment

  • Morphology - Imaging

    Charles Nicaise (Manager) & Francesca Cecchet (Manager)

    Technological Platform Morphology - Imaging

    Facility/equipment: Technological Platform

  • Activities

    • 1 Participation in conference

    Organelle Crosstalk in Membrane Dynamics and Cell Signalling

    Thierry Arnould (Poster)

    26 Oct 201529 Oct 2015

    Activity: Participating in or organising an event typesParticipation in conference

    Student Theses

    Etude du facteur de transcription CHOP10/GADD153 Dans les macrophages RAW264.7 exposés à Brucella abortus

    Author: LOBET, E., 2012

    Supervisor: Arnould, T. (Supervisor)

    Student thesis: Master typesMaster in Biochemistry and molecular and cellular Biology

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