Projects per year
Abstract
Eukaryotic cells developed strategies to detect and eradicate infections. The innate immune system, which is the first line of defence against invading pathogens, relies on the recognition of molecular patterns conserved among pathogens. Pathogen associated molecular pattern binding to pattern recognition receptor triggers the activation of several signalling pathways leading to the establishment of a pro-inflammatory state required to control the infection.In addition, pathogens evolved to subvert those responses (with passive and active strategies) allowing their entry and persistence in the host cells and tissues. Indeed, several bacteria actively manipulate immune system or interfere with the cell fate for their own benefit. One can imagine that bacterial effectors can potentially manipulate every single organelle in the cell. However, the multiple functions fulfilled by mitochondria especially their involvement in the regulation of innate immune response, make mitochondria a target of choice for bacterial pathogens as they are not only a key component of the central metabolism through ATP production and synthesis of various biomolecules but they also take part to cell signalling through ROS production and control of calcium homeostasis as well as the control of cell survival/programmed cell death. Furthermore, considering that mitochondria derived from an ancestral bacterial endosymbiosis, it is not surprising that a special connection does exist between this organelle and bacteria. In this review, we will discuss different mitochondrial functions that are affected during bacterial infection as well as different strategies developed by bacterial pathogens to subvert functions related to calcium homeostasis, maintenance of redox status and mitochondrial morphology.
Original language | English |
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Pages (from-to) | 173-185 |
Number of pages | 13 |
Journal | Biochemical Pharmacology |
Volume | 94 |
Issue number | 3 |
Early online date | 20 Feb 2015 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Keywords
- Bacteria
- Calcium
- Immunity
- Metabolism
- Mitochondria
- MtROS
Fingerprint
Dive into the research topics of 'Mitochondria : A target for bacteria'. Together they form a unique fingerprint.Projects
- 1 Finished
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PAI n°P7/28 - MICRODEV: PAI n°P7/28 - MICRODEV: Role of developmental processes in the virulence of human pathogens : from molecular mechanisms to novel therapeutic targets
LETESSON, J.-J. (CoI), Coenye, T. (PI), Van Dijck, P. (CoI), Van Melderen, L. (CoI), HOLS, P. (CoI) & De Bolle, X. (CoI)
1/10/12 → 30/09/17
Project: Research
Equipment
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Biological Security Laboratory Level 3 (BL3)
De Bolle, X. (Manager)
Technological Platform: Biological Security Laboratory Level 3Facility/equipment: Technological Platform
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Light Microscopy
Renard, H.-F. (Manager), Forrester, A. (Manager), Demazy, C. (Other) & Ledoux, B. (Manager)
Technological Platform Morphology - ImagingFacility/equipment: Equipment
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Morphology - Imaging
Cecchet, F. (Manager) & Renard, H.-F. (Manager)
Technological Platform Morphology - ImagingFacility/equipment: Technological Platform
Activities
- 1 Participation in conference
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Organelle Crosstalk in Membrane Dynamics and Cell Signalling
Arnould, T. (Poster)
26 Oct 2015 → 29 Oct 2015Activity: Participating in or organising an event types › Participation in conference
Student theses
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Etude du facteur de transcription CHOP10/GADD153 Dans les macrophages RAW264.7 exposés à Brucella abortus
LOBET, E. (Author)Arnould, T. (Supervisor), 2012Student thesis: Master types › Master in Biochemistry and molecular and cellular Biology
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