Abstract

Eukaryotic cells developed strategies to detect and eradicate infections. The innate immune system, which is the first line of defence against invading pathogens, relies on the recognition of molecular patterns conserved among pathogens. Pathogen associated molecular pattern binding to pattern recognition receptor triggers the activation of several signalling pathways leading to the establishment of a pro-inflammatory state required to control the infection.In addition, pathogens evolved to subvert those responses (with passive and active strategies) allowing their entry and persistence in the host cells and tissues. Indeed, several bacteria actively manipulate immune system or interfere with the cell fate for their own benefit. One can imagine that bacterial effectors can potentially manipulate every single organelle in the cell. However, the multiple functions fulfilled by mitochondria especially their involvement in the regulation of innate immune response, make mitochondria a target of choice for bacterial pathogens as they are not only a key component of the central metabolism through ATP production and synthesis of various biomolecules but they also take part to cell signalling through ROS production and control of calcium homeostasis as well as the control of cell survival/programmed cell death. Furthermore, considering that mitochondria derived from an ancestral bacterial endosymbiosis, it is not surprising that a special connection does exist between this organelle and bacteria. In this review, we will discuss different mitochondrial functions that are affected during bacterial infection as well as different strategies developed by bacterial pathogens to subvert functions related to calcium homeostasis, maintenance of redox status and mitochondrial morphology.

Original languageEnglish
Pages (from-to)173-185
Number of pages13
JournalBiochemical Pharmacology
Volume94
Issue number3
Early online date20 Feb 2015
DOIs
Publication statusPublished - 1 Apr 2015

Fingerprint

Mitochondria
Pathogens
Bacteria
Organelles
Immune system
Immune System
Homeostasis
Calcium
Pattern Recognition Receptors
Symbiosis
Cell signaling
Eukaryotic Cells
Infection Control
Bacterial Infections
Innate Immunity
Oxidation-Reduction
Biomolecules
Cell death
Cell Survival
Cell Death

Keywords

  • Bacteria
  • Calcium
  • Immunity
  • Metabolism
  • Mitochondria
  • MtROS

Cite this

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title = "Mitochondria : A target for bacteria",
abstract = "Eukaryotic cells developed strategies to detect and eradicate infections. The innate immune system, which is the first line of defence against invading pathogens, relies on the recognition of molecular patterns conserved among pathogens. Pathogen associated molecular pattern binding to pattern recognition receptor triggers the activation of several signalling pathways leading to the establishment of a pro-inflammatory state required to control the infection.In addition, pathogens evolved to subvert those responses (with passive and active strategies) allowing their entry and persistence in the host cells and tissues. Indeed, several bacteria actively manipulate immune system or interfere with the cell fate for their own benefit. One can imagine that bacterial effectors can potentially manipulate every single organelle in the cell. However, the multiple functions fulfilled by mitochondria especially their involvement in the regulation of innate immune response, make mitochondria a target of choice for bacterial pathogens as they are not only a key component of the central metabolism through ATP production and synthesis of various biomolecules but they also take part to cell signalling through ROS production and control of calcium homeostasis as well as the control of cell survival/programmed cell death. Furthermore, considering that mitochondria derived from an ancestral bacterial endosymbiosis, it is not surprising that a special connection does exist between this organelle and bacteria. In this review, we will discuss different mitochondrial functions that are affected during bacterial infection as well as different strategies developed by bacterial pathogens to subvert functions related to calcium homeostasis, maintenance of redox status and mitochondrial morphology.",
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Mitochondria : A target for bacteria. / Lobet, Elodie; Letesson, Jean-Jacques; Arnould, Thierry.

In: Biochemical Pharmacology, Vol. 94, No. 3, 01.04.2015, p. 173-185.

Research output: Contribution to journalArticle

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AU - Letesson, Jean-Jacques

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