MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection

Julien Lemaire, Ghada Mkannez, Fatma Z Guerfali, Cindy Gustin, Hanène Attia, Rabiaa M Sghaier, Koussay Dellagi, Dhafer Laouini, Patricia Renard, Sysco Consortium

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Abstract

Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases that are mainly embedded in impoverished populations. To establish successful infection and ensure their own survival, Leishmania have developed sophisticated strategies to subvert the host macrophage responses. Despite a wealth of gained crucial information, these strategies still remain poorly understood. MicroRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide non-coding RNAs, are described to participate in the regulation of almost every cellular process investigated so far. They regulate the expression of target genes both at the levels of mRNA stability and translation; changes in their expression have a profound effect on their target transcripts.
Original languageEnglish
Pages (from-to)e2478
JournalPLoS neglected tropical diseases
Volume7
Issue number10
DOIs
Publication statusPublished - 2013

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