Measuring Direct Oral Anticoagulants

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)


Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Subtitle of host publicationMethods and Protocols
EditorsEmmanuel J. Favaloro, Giuseppe Lippi
PublisherHumana Press Inc.
Number of pages9
ISBN (Electronic)978-1-4939-7196-1
ISBN (Print)978-1-4939-7194-7
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Anti-Xa
  • Apixaban
  • Dabigatran
  • Dilute thrombin time
  • Direct oral anticoagulants
  • Ecarin
  • Edoxaban
  • Rivaroxaban

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  • Cite this

    Douxfils, J. (2017). Measuring Direct Oral Anticoagulants. In E. J. Favaloro, & G. Lippi (Eds.), Methods in Molecular Biology: Methods and Protocols (pp. 217-225). (Methods in Molecular Biology; Vol. 1646). Humana Press Inc..