Measuring Direct Oral Anticoagulants

Jonathan Douxfils

doi:10.1007/978-1-4939-7196-1_18

Measuring Direct Oral Anticoagulants

Research output: Contribution in Book/Catalog/Report/Conference proceeding › Chapter

Abstract

Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

Original language	English
Title of host publication	Methods in Molecular Biology
Subtitle of host publication	Methods and Protocols
Editors	Emmanuel J. Favaloro, Giuseppe Lippi
Publisher	Humana Press Inc.
Pages	217-225
Number of pages	9
ISBN (Electronic)	978-1-4939-7196-1
ISBN (Print)	978-1-4939-7194-7
DOIs	https://doi.org/10.1007/978-1-4939-7196-1_18
Publication status	Published - 1 Jan 2017

Publication series

Name	Methods in Molecular Biology
Volume	1646
ISSN (Print)	1064-3745

Keywords

Anti-Xa
Apixaban
Dabigatran
Dilute thrombin time
Direct oral anticoagulants
Ecarin
Edoxaban
Rivaroxaban

Access to Document

10.1007/978-1-4939-7196-1_18

Cite this

@inbook{9559bcd30f844a519c2645cbc5219bfd,

title = "Measuring Direct Oral Anticoagulants",

abstract = "Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).",

keywords = "Anti-Xa, Apixaban, Dabigatran, Dilute thrombin time, Direct oral anticoagulants, Ecarin, Edoxaban, Rivaroxaban",

author = "Jonathan Douxfils",

year = "2017",

month = jan,

day = "1",

doi = "10.1007/978-1-4939-7196-1_18",

language = "English",

isbn = "978-1-4939-7194-7",

series = "Methods in Molecular Biology",

publisher = "Humana Press Inc.",

pages = "217--225",

editor = "Favaloro, {Emmanuel J.} and Lippi, {Giuseppe }",

booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Measuring Direct Oral Anticoagulants

AU - Douxfils, Jonathan

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

AB - Direct oral anticoagulants (DOACs) can be quantified using methods that can be performed in any clinical or research laboratory using manual or automated instrument platforms. Dabigatran etexilate, the oral direct thrombin inhibitor, can be quantified by drug-calibrated clot or chromogenic-based assays using either thrombin or ecarin as substrates. Oral direct anti-Xa inhibitors, such as rivaroxaban, apixaban, and edoxaban, can be quantified with drug-calibrated anti-Xa kits or reagents as typically used for measuring heparins (unfractionated, low molecular weight, or pentasaccharides).

KW - Anti-Xa

KW - Apixaban

KW - Dabigatran

KW - Dilute thrombin time

KW - Direct oral anticoagulants

KW - Ecarin

KW - Edoxaban

KW - Rivaroxaban

UR - http://www.scopus.com/inward/record.url?scp=85027533768&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-7196-1_18

DO - 10.1007/978-1-4939-7196-1_18

M3 - Chapter

SN - 978-1-4939-7194-7

T3 - Methods in Molecular Biology

SP - 217

EP - 225

BT - Methods in Molecular Biology

A2 - Favaloro, Emmanuel J.

A2 - Lippi, Giuseppe

PB - Humana Press Inc.

ER -

Measuring Direct Oral Anticoagulants

Abstract

Publication series

Keywords

Access to Document

Other files and links

Fingerprint

Cite this