Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

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Abstract

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

Original languageEnglish
Pages (from-to)168-203
Number of pages36
JournalCells
Volume1
Issue number2
DOIs
Publication statusPublished - 2012

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Autophagy
Lipid Metabolism
Proteins
Degradation
Metabolic Diseases
Organelles
Neoplasms

Cite this

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title = "Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins",
abstract = "Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.",
author = "St{\'e}phane Demine and S{\'e}bastien Michel and Kayleen Vannuvel and Ana{\"i}s Wanet and Patricia Renard and Thierry Arnould",
year = "2012",
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AU - Demine, Stéphane

AU - Michel, Sébastien

AU - Vannuvel, Kayleen

AU - Wanet, Anaïs

AU - Renard, Patricia

AU - Arnould, Thierry

PY - 2012

Y1 - 2012

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AB - Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

U2 - 10.3390/cells1020168

DO - 10.3390/cells1020168

M3 - Article

VL - 1

SP - 168

EP - 203

JO - Cells

JF - Cells

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