Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

Stéphane Demine, Sébastien Michel, Kayleen Vannuvel, Anaïs Wanet, Patricia Renard, Thierry Arnould

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Abstract

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

Original languageEnglish
Pages (from-to)168-203
Number of pages36
JournalCells
Volume1
Issue number2
DOIs
Publication statusPublished - 2012

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