Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

Stéphane Demine; Sébastien Michel; Kayleen Vannuvel; Anaïs Wanet; Patricia Renard; Thierry Arnould

doi:10.3390/cells1020168

Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

Stéphane Demine, Sébastien Michel, Kayleen Vannuvel, Anaïs Wanet, Patricia Renard, Thierry Arnould

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Abstract

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.

Original language	English
Pages (from-to)	168-203
Number of pages	36
Journal	Cells
Volume	1
Issue number	2
DOIs	https://doi.org/10.3390/cells1020168
Publication status	Published - 2012

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10.3390/cells1020168

2012-06 Demine-CellsFinal published version, 695 KB

Effects of a mitochondrial uncoupling on lipolysis and adipokine expression in 3T3-L1 murine adipocytes
Demine, S. (Author), Arnould, T. (Supervisor), Jadot, M. (Co-Supervisor), De Bolle, X. (President), Raes, M. (Jury), KEIJER, J. (Jury) & Bertrand, L. (Jury), 26 Apr 2016
Student thesis: Doc types › Doctor of Sciences

Cite this

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abstract = "Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.",

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AU - Demine, Stéphane

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AU - Vannuvel, Kayleen

AU - Wanet, Anaïs

AU - Renard, Patricia

AU - Arnould, Thierry

PY - 2012

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Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins

Abstract

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Student theses

Effects of a mitochondrial uncoupling on lipolysis and adipokine expression in 3T3-L1 murine adipocytes

Cite this