Long-term physico-chemical stability of 5-fluorouracile at standardised rounded doses (SRD) in MyFuser® portable infusion pump

Mélanie Closset, Sabrina Onorati, Marie Lise Colsoul, Nicolas Goderniaux, Benoît Bihin, Jacques Jamart, Laura Soumoy, Jean Daniel Hecq, Pascal Odou, Laurence Galanti

Research output: Contribution to journalArticlepeer-review

Abstract

Management of chemotherapies is a strategic issue for european healthcare. Dose-banding enables to reduce waiting time of patients in day care units and drug wastage. The aim of this study was to assess the stability of 5-Fluorouracile (5-FU) at standardised rounded doses of 4 and 5 g in MyFuser® portable infusion pump for in-advance preparation. Ten MyFuser® (4 and 5 gr 5-FU added to NaCl 0.9%) were prepared under aseptic conditions and stored at room temperature (23 ± 2 °C) for 28 days then at 30 °C for three days. Physical stability tests were periodically performed: visual and microscopic inspection, pH measurements and optical densities. The concentration of solutions was measured by High Performance Liquid Chromatography/UV detector. Results confirm the stability of 5-FU at selected SRD of 4 g and 5 g with NaCl 0.9% in MyFuser® for at least 28 days at room temperature and three days at 30 °C, allowing in-advance preparation.

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalJournal of Chemotherapy
Volume33
Issue number7
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • 5-FU
  • Chromatography
  • CIVAS
  • Dose-Banding
  • portable infusion pump
  • stability study

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