Abstract

Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.

Original languageEnglish
Pages (from-to)1371-1387
Number of pages17
JournalCurrent Drug and Metabolism
Volume13
Issue number10
DOIs
Publication statusPublished - 1 Dec 2012

Fingerprint

Lysosomes
Lipids
Membranes
Macromolecules
Lysosomal Storage Diseases
Autophagy
Endocytosis
Phagocytosis
Organelles
Enzymes
Chemical analysis

Keywords

  • Lipids
  • Lysosomal hydrolysis and lysosomal trafficking
  • Lysosomes

Cite this

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Lipids and lysosomes. / Hamer, Isabelle; Van Beersel, Guillaume; Arnould, Thierry; Jadot, Michel.

In: Current Drug and Metabolism, Vol. 13, No. 10, 01.12.2012, p. 1371-1387.

Research output: Contribution to journalArticle

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