Lipids and lysosomes

Isabelle Hamer; Guillaume Van Beersel; Thierry Arnould; Michel Jadot

doi:10.2174/138920012803762684

Lipids and lysosomes

Isabelle Hamer, Guillaume Van Beersel, Thierry Arnould, Michel Jadot

Research output: Contribution to journal › Article › peer-review

Abstract

Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.

Original language	English
Pages (from-to)	1371-1387
Number of pages	17
Journal	Current Drug and Metabolism
Volume	13
Issue number	10
DOIs	https://doi.org/10.2174/138920012803762684
Publication status	Published - 1 Dec 2012

Keywords

Lipids
Lysosomal hydrolysis and lysosomal trafficking
Lysosomes

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10.2174/138920012803762684

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AU - Hamer, Isabelle

AU - Van Beersel, Guillaume

AU - Arnould, Thierry

AU - Jadot, Michel

PY - 2012/12/1

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N2 - Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.

AB - Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.

KW - Lipids

KW - Lysosomal hydrolysis and lysosomal trafficking

KW - Lysosomes

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ER -

Lipids and lysosomes

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Organelle Crosstalk in Membrane Dynamics and Cell Signalling

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Lipids and lysosomes

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Organelle Crosstalk in Membrane Dynamics and Cell Signalling

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