Linking ABC transporters to the hallmarks of cancer

Research output: Contribution to journalReview articlepeer-review


Human ATP-binding cassette (ABC) transporters are ubiquitously expressed and transport a broad range of endogenous and xenobiotic substrates across extra- and intracellular membranes. Mutations in ABC genes cause 21 monogenic diseases, and polymorphisms in these genes are associated with susceptibility to complex diseases. ABC transporters also play a major role in drug bioavailability, and they mediate multidrug resistance in cancer. At least 13 ABC transporters were shown to be involved in drug resistance in vitro. In the past decade, efforts have been made to elucidate their roles in tumor biology. Herein, we explore their involvement in tumorigenesis, focusing on the hallmarks of cells as they make their way from normalcy to neoplastic growth states.

Original languageEnglish
Pages (from-to)124-134
Number of pages11
JournalTrends in Cancer
Issue number2
Publication statusPublished - 24 Oct 2023


  • ABC transporters
  • cancer drivers
  • hallmarks of cancer
  • multidrug resistance


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