LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

M R Sarker; M P Sory; A P Boyd; M Iriarte; G R Cornelis

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

M R Sarker, M P Sory, A P Boyd, M Iriarte, G R Cornelis

Research output: Contribution to journal › Article › peer-review

Abstract

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

Original language	English
Pages (from-to)	2976-9
Number of pages	4
Journal	Infection and Immunity
Volume	66
Issue number	6
Publication status	Published - 1998

Cite this

@article{93eae472721d40d99d1c95b380bb1bed,

title = "LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells",

abstract = "Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.",

author = "Sarker, {M R} and Sory, {M P} and Boyd, {A P} and M Iriarte and Cornelis, {G R}",

year = "1998",

language = "English",

volume = "66",

pages = "2976--9",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

AU - Sarker, M R

AU - Sory, M P

AU - Boyd, A P

AU - Iriarte, M

AU - Cornelis, G R

PY - 1998

Y1 - 1998

N2 - Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

AB - Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.

M3 - Article

C2 - 9596775

SN - 0019-9567

VL - 66

SP - 2976

EP - 2979

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells

Abstract

Fingerprint

Cite this