Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Zhaokui Jin, Yanyuan Wen, Liwei Xiong, Tian Yang, Penghe Zhao, Liwei Tan, Tianfu Wang, Zhiyong Qian, Bao Lian Su, Qianjun He

Research output: Contribution to journalArticlepeer-review

Abstract

A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.

Original languageEnglish
Pages (from-to)5557-5560
Number of pages4
JournalChemical Communications
Volume53
Issue number40
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

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