Abstract
A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.
Original language | English |
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Pages (from-to) | 5557-5560 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 53 |
Issue number | 40 |
DOIs | |
Publication status | Published - 1 Jan 2017 |
Externally published | Yes |