Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep

Thien Thanh Dang-Vu, Maxime Bonjean, Manuel Schabus, Mélanie Boly, Annabelle Darsaud, Martin Desseilles, Christian Degueldre, Evelyne Balteau, Christophe Phillips, André Luxen, Terrence J Sejnowski, Pierre Maquet

Research output: Contribution to journalArticlepeer-review

Abstract

Humans are less responsive to the surrounding environment during sleep. However, the extent to which the human brain responds to external stimuli during sleep is uncertain. We used simultaneous EEG and functional MRI to characterize brain responses to tones during wakefulness and non-rapid eye movement (NREM) sleep. Sounds during wakefulness elicited responses in the thalamus and primary auditory cortex. These responses persisted in NREM sleep, except throughout spindles, during which they became less consistent. When sounds induced a K complex, activity in the auditory cortex was enhanced and responses in distant frontal areas were elicited, similar to the stereotypical pattern associated with slow oscillations. These data show that sound processing during NREM sleep is constrained by fundamental brain oscillatory modes (slow oscillations and spindles), which result in a complex interplay between spontaneous and induced brain activity. The distortion of sensory information at the thalamic level, especially during spindles, functionally isolates the cortex from the environment and might provide unique conditions favorable for off-line memory processing.
Original languageEnglish
Pages (from-to)15438-43
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number37
DOIs
Publication statusPublished - 13 Sep 2011

Keywords

  • Adolescent
  • Adult
  • Audiometry, Pure-Tone
  • Brain Mapping
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Sleep, REM
  • Wakefulness
  • Young Adult

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