Projects per year
Abstract
Here we demonstrate how sum frequency generation (SFG), a vibrational spectroscopy based on a nonlinear three-photons mixing process, may provide a direct and unique fingerprint of bio-recognition, with intrinsically discriminating unspecific adsorption, thanks to the high sensitivity of the second order nonlinear optical (NLO) response to preferential molecular orientation and symmetry properties. As proof of concept, we have detected the biological event at the solid/liquid interface of a model bio-active antigen platform, based on a solid-supported hybrid lipid bilayer (ss-HLB) of a 2,4-dinitrophenyl (DNP) lipid, towards a monoclonal mouse anti-DNP complementary antibody.
Original language | English |
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Pages (from-to) | 2610 |
Journal | ChemPhysChem |
Volume | 17 |
DOIs | |
Publication status | Published - 5 Sep 2016 |
Projects
- 1 Active
Equipment
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Optics, Lasers and spectroscopy
Muriel Lepere (Manager)
Technological Platform Optics, Lasers and spectroscopyFacility/equipment: Technological Platform
Activities
- 2 Participation in conference
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Biointerfaces Symposium
Francesca Cecchet (Invited Speaker)
12 May 2015Activity: Participating in or organising an event types › Participation in conference
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Action Nationale de Formation du CNRS en "Spectroscopie et Imagerie d’interfaces materiaux- molecules du vivant"
Francesca Cecchet (Invited Speaker)
15 Oct 2014 → 17 Oct 2014Activity: Participating in or organising an event types › Participation in conference
Student Theses
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Study of the interactions between gold nanoparticles and models of cell membranes by second order nonlinear optical spectroscopies
Author: Toledo-Fuentes, X., 28 Oct 2015Supervisor: Cecchet, F. (Supervisor), Lucas, S. (President), Caudano, Y. (Jury), Champagne, B. (Jury), Benichou, E. (External person) (Jury) & Losada-Perez, P. (External person) (Jury)
Student thesis: Doc types › Doctor of Sciences