Activities per year
Mitochondria-to-nucleus communication, known as retrograde signaling, is important to adjust the nuclear gene expression in response to organelle dysfunction. Among the transcription factors described to respond to mitochondrial stress, CHOP-10 is activated by respiratory chain inhibition, mitochondrial accumulation of unfolded proteins and mtDNA mutations. In this study, we show that altered/impaired expression of mtDNA induces CHOP-10 expression in a signaling pathway that depends on the eIF2α/ATF4 axis of the integrated stress response rather than on the mitochondrial unfolded protein response.
- C/EBP homologous protein 10 (CHOP-10)
- Integrated stress response (ISR)
- Mitochondria unfolded protein response (mtUPR)
- Mitochondrial dysfunction
- MtDNA depletion
FingerprintDive into the research topics of 'Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response'. Together they form a unique fingerprint.
- 1 Participation in workshop, seminar, course
Thierry Arnould (Poster)23 May 2016 → 26 May 2016
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Study of the transcriptional responses to the inhibition of the expression of the mitochondrial genome: analysis of the activation of the mitochondrial unfolded protein response and the integrated stress responseAuthor: Michel, S., 24 Oct 2014
Student thesis: Doc types › Doctor of Sciences