TY - JOUR

T1 - Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation

AU - Wéra, A. C.

AU - Barazzuol, L.

AU - Jeynes, J. C G

AU - Merchant, M. J.

AU - Suzuki, M.

AU - Kirkby, K. J.

PY - 2014/8/7

Y1 - 2014/8/7

N2 - It is well known that broad beam irradiation with heavy ions leads to variation in the number of hit(s) received by each cell as the distribution of particles follows the Poisson statistics. Although the nucleus area will determine the number of hit(s) received for a given dose, variation amongst its irradiated cell population is generally not considered. In this work, we investigate the effect of the nucleus area's distribution on the survival fraction. More specifically, this work aims to explain the deviation, or tail, which might be observed in the survival fraction at high irradiation doses. For this purpose, the nucleus area distribution was added to the beam Poisson statistics and the Linear-Quadratic model in order to fit the experimental data. As shown in this study, nucleus size variation, and the associated Poisson statistics, can lead to an upward survival trend after broad beam irradiation. The influence of the distribution parameters (mean area and standard deviation) was studied using a normal distribution, along with the Linear-Quadratic model parameters (and β). Finally, the model proposed here was successfully tested to the survival fraction of LN18 cells irradiated with a 85 keV μm-1 carbon ion broad beam for which the distribution in the area of the nucleus had been determined.

AB - It is well known that broad beam irradiation with heavy ions leads to variation in the number of hit(s) received by each cell as the distribution of particles follows the Poisson statistics. Although the nucleus area will determine the number of hit(s) received for a given dose, variation amongst its irradiated cell population is generally not considered. In this work, we investigate the effect of the nucleus area's distribution on the survival fraction. More specifically, this work aims to explain the deviation, or tail, which might be observed in the survival fraction at high irradiation doses. For this purpose, the nucleus area distribution was added to the beam Poisson statistics and the Linear-Quadratic model in order to fit the experimental data. As shown in this study, nucleus size variation, and the associated Poisson statistics, can lead to an upward survival trend after broad beam irradiation. The influence of the distribution parameters (mean area and standard deviation) was studied using a normal distribution, along with the Linear-Quadratic model parameters (and β). Finally, the model proposed here was successfully tested to the survival fraction of LN18 cells irradiated with a 85 keV μm-1 carbon ion broad beam for which the distribution in the area of the nucleus had been determined.

KW - heavy charged particles

KW - lq model

KW - nucleus area distribution

KW - poisson statistics

KW - survival fraction

UR - http://www.scopus.com/inward/record.url?scp=84904739864&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/59/15/4197

DO - 10.1088/0031-9155/59/15/4197

M3 - Article

C2 - 25017303

AN - SCOPUS:84904739864

SN - 0031-9155

VL - 59

SP - 4197

EP - 4211

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 15

ER -