Increasing Diversity of Biological Membrane Fission Mechanisms

Henri François Renard, Ludger Johannes, Pierre Morsomme

Research output: Contribution to journalReview articlepeer-review

Abstract

Membrane fission is essential to life. It is required for many fundamental cellular processes, as diverse as cyto- and karyokinesis, organelle division, membrane repair, and membrane trafficking and endocytosis. While membrane fission was originally seen as resulting from the action of mechanoenzymes such as dynamin, it is clear that the reality is more complex. In this review, we propose an updated overview of fission mechanisms, and try to extract essential requirements for each. We also present examples of cellular processes that involve these fission mechanisms. Finally, we list pending questions, whether they are specific to a peculiar fission mechanism or more general to the field.

Original languageEnglish
Pages (from-to)274-286
Number of pages13
JournalTrends in Cell Biology
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2018
Externally publishedYes

Keywords

  • fission
  • membranes
  • scission
  • Animals
  • Models, Biological
  • Cytokinesis/physiology
  • Humans
  • Cell Membrane/physiology
  • Dynamins/metabolism
  • Endosomal Sorting Complexes Required for Transport/metabolism
  • Cell Nucleus Division/physiology
  • Endocytosis/physiology

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