TY - JOUR
T1 - In vivo biomarkers of estrogenicity
T2 - Limitation of interpretation in wild environment
AU - Nadzialek, S.
AU - Depiereux, S.
AU - Mandiki, Robert
AU - Kestemont, P.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - In the literature, multiple sample schemes have been developed to assess the environmental impacts of endocrine-disruptor compounds (EDCs) from sewage treatment plant (STPs). In the present work, the plan study was designed by sampling upstream and downstream wild populations of gudgeons from two STP stations (La Roche and Rochefort, Belgium). Biomarkers of feminization were assayed, such as vitellogenin expression and ovotestis screening. Parameters involved in steroidogenesis (sex steroids and brain aromatase activity) were also investigated to better characterize interactions between living organisms coping with a complex mixture of compounds loaded by treated effluent. Results displayed moderate differences between upstream and downstream populations of wild gudgeons. Moreover, accounted differences have demonstrated the difficulty of characterizing the mixture of compounds to which fish are exposed in the aquatic milieu. Actually, physiological responses were not representative of a particular group of EDC (e.g., estrogenlike compounds) but instead confirm an association between different categories of compounds. Even if powerful biomarkers of estrogenicty were developed, the interpretation of the response profile remains limited through in vivo parameters due to the complex association between compounds of various origins.
AB - In the literature, multiple sample schemes have been developed to assess the environmental impacts of endocrine-disruptor compounds (EDCs) from sewage treatment plant (STPs). In the present work, the plan study was designed by sampling upstream and downstream wild populations of gudgeons from two STP stations (La Roche and Rochefort, Belgium). Biomarkers of feminization were assayed, such as vitellogenin expression and ovotestis screening. Parameters involved in steroidogenesis (sex steroids and brain aromatase activity) were also investigated to better characterize interactions between living organisms coping with a complex mixture of compounds loaded by treated effluent. Results displayed moderate differences between upstream and downstream populations of wild gudgeons. Moreover, accounted differences have demonstrated the difficulty of characterizing the mixture of compounds to which fish are exposed in the aquatic milieu. Actually, physiological responses were not representative of a particular group of EDC (e.g., estrogenlike compounds) but instead confirm an association between different categories of compounds. Even if powerful biomarkers of estrogenicty were developed, the interpretation of the response profile remains limited through in vivo parameters due to the complex association between compounds of various origins.
UR - http://www.scopus.com/inward/record.url?scp=79955939283&partnerID=8YFLogxK
U2 - 10.1007/s00244-010-9548-8
DO - 10.1007/s00244-010-9548-8
M3 - Article
AN - SCOPUS:79955939283
SN - 0090-4341
VL - 60
SP - 471
EP - 478
JO - Archives of Environmental Contamination and Toxicology
JF - Archives of Environmental Contamination and Toxicology
IS - 3
ER -