In vivo biodistribution of amino-functionalized ceria nanoparticles in rats using positron emission tomography

Santiago Rojas; Juan Domingo Gispert; Sergio Abad; Mireia Buaki-Sogo; Victor M. Victor; Hermenegildo Garcia; Jose Raúl Herance

doi:10.1021/mp300382n

In vivo biodistribution of amino-functionalized ceria nanoparticles in rats using positron emission tomography

Santiago Rojas, Juan Domingo Gispert, Sergio Abad, Mireia Buaki-Sogo, Victor M. Victor, Hermenegildo Garcia, Jose Raúl Herance

Research output: Contribution to journal › Article › peer-review

Abstract

A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with ¹⁸F to study their in vivo biodistribution in rats by positron emission tomography (PET). The ¹⁸F isotope was anchored by reaction of N-succinimidyl 4-[¹⁸F]fluorobenzoate (¹⁸F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.

Original language	English
Pages (from-to)	3543-3550
Number of pages	8
Journal	Molecular Pharmaceutics
Volume	9
Issue number	12
DOIs	https://doi.org/10.1021/mp300382n
Publication status	Published - 3 Dec 2012
Externally published	Yes

Keywords

ceria nanoparticles
in vivo evaluation
PET
pharmacokinetics
rodent

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abstract = "A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with 18F to study their in vivo biodistribution in rats by positron emission tomography (PET). The 18F isotope was anchored by reaction of N-succinimidyl 4-[18F]fluorobenzoate (18F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.",

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T1 - In vivo biodistribution of amino-functionalized ceria nanoparticles in rats using positron emission tomography

AU - Rojas, Santiago

AU - Gispert, Juan Domingo

AU - Abad, Sergio

AU - Buaki-Sogo, Mireia

AU - Victor, Victor M.

AU - Garcia, Hermenegildo

AU - Herance, Jose Raúl

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AB - A variety of nanoparticles have been proposed for several biomedical applications. To gauge the therapeutic potential of these nanoparticles, in vivo biodistribution is essential and mandatory. In the present study, ceria nanoparticles (5 nm average particle size) were labeled with 18F to study their in vivo biodistribution in rats by positron emission tomography (PET). The 18F isotope was anchored by reaction of N-succinimidyl 4-[18F]fluorobenzoate (18F-SFB) with a modified nanoparticle surface obtained by silylation with 3-aminopropylsilyl. Radiolabeled ceria nanoparticles accumulated mainly in lungs, spleen, and liver. Metabolic products of the radiolabeled nanoparticulate material were excreted into the urinary tract.

KW - ceria nanoparticles

KW - in vivo evaluation

KW - PET

KW - pharmacokinetics

KW - rodent

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In vivo biodistribution of amino-functionalized ceria nanoparticles in rats using positron emission tomography

Abstract

Keywords

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