In vitro models of dermatophyte infection to investigate epidermal barrier alterations

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Abstract

Fungal infections of the skin, known as dermatophytoses, are initiated at the epidermal barrier and lead to dysfunctions of the stratum corneum and cornified skin appendages. Dermatophytosis affects a significant part of the human population and, despite the availability of effective treatments, its prevalence is still increasing. Numerous dermatophyte species are able to induce lesions in both animals and humans, with different clinical pictures and host inflammatory responses. The understanding of the infectious process and of tissue responses has been impeded by discrepancies between observations in vivo or in research models. Indeed, cells cultured as monolayers do not undergo the keratinization process required to study the adherence and invasion of dermatophytes. Animal models lack relevance to study human dermatophytosis because of species-specific differences in the development of lesions and inflammatory responses. This review focuses on the recent development of cultured human skin equivalents, which partly overcomes those limitations and allows improved understanding of the pathogenesis of dermatophytosis in human being, especially the impacts of infection on epidermal barrier integrity.

Original languageEnglish
Pages (from-to)915-922
Number of pages8
JournalExperimental dermatology
Volume27
Issue number8
Early online date29 Jun 2018
DOIs
Publication statusPublished - 28 Aug 2018

Keywords

  • epidermal barrier
  • fungal infection
  • model of dermatophytosis
  • reconstructed human epidermis
  • trichophyton rubrum

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    Student Theses

    Pathogénie d’une dermatophytose (Trichophyton rubrum) sur épiderme humain reconstruit

    Author: Faway, É., 7 Mar 2018

    Supervisor: Lambert De Rouvroit, C. (Co-Supervisor), Poumay, Y. (Supervisor), De Bolle, X. (President), Del Marmol, V. (External person) (Jury), Jonca, N. (External person) (Jury), Mignon, B. R. (External person) (Jury) & Monod, M. (External person) (Jury)

    Student thesis: Doc typesDoctor of Biomedical and Pharmaceutical Sciences

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