In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

Y Henrotin; X de Leval; M Mathy-Hartet; A Mouithys-Mickalad; G Deby-Dupont; J M Dogné; J Delarge; J Y Reginster

In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

Y Henrotin, X de Leval, M Mathy-Hartet, A Mouithys-Mickalad, G Deby-Dupont, J M Dogné, J Delarge, J Y Reginster

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.

Original language	English
Pages (from-to)	391-9
Number of pages	9
Journal	Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Volume	50
Issue number	8
Publication status	Published - Aug 2001

Keywords

Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal
Cells, Cultured
Chondrocytes
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Cytokines
DNA
Diclofenac
Dinoprostone
Humans
Inflammation Mediators
Interleukin-1
Isoenzymes
Membrane Proteins
Middle Aged
Nitric Oxide
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Prostaglandin-Endoperoxide Synthases
Reverse Transcriptase Polymerase Chain Reaction

Cite this

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title = "In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators",

abstract = "To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.",

keywords = "Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Cells, Cultured, Chondrocytes, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Cytokines, DNA, Diclofenac, Dinoprostone, Humans, Inflammation Mediators, Interleukin-1, Isoenzymes, Membrane Proteins, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Prostaglandin-Endoperoxide Synthases, Reverse Transcriptase Polymerase Chain Reaction",

author = "Y Henrotin and {de Leval}, X and M Mathy-Hartet and A Mouithys-Mickalad and G Deby-Dupont and Dogn{\'e}, {J M} and J Delarge and Reginster, {J Y}",

year = "2001",

month = aug,

language = "English",

volume = "50",

pages = "391--9",

journal = "Inflammation research : official journal of the European Histamine Research Society ... [et al.]",

issn = "1023-3830",

publisher = "Birkhauser Verlag Basel",

number = "8",

}

TY - JOUR

T1 - In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

AU - Henrotin, Y

AU - de Leval, X

AU - Mathy-Hartet, M

AU - Mouithys-Mickalad, A

AU - Deby-Dupont, G

AU - Dogné, J M

AU - Delarge, J

AU - Reginster, J Y

PY - 2001/8

Y1 - 2001/8

N2 - To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.

AB - To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Cells, Cultured

KW - Chondrocytes

KW - Cyclooxygenase 1

KW - Cyclooxygenase 2

KW - Cyclooxygenase 2 Inhibitors

KW - Cyclooxygenase Inhibitors

KW - Cytokines

KW - DNA

KW - Diclofenac

KW - Dinoprostone

KW - Humans

KW - Inflammation Mediators

KW - Interleukin-1

KW - Isoenzymes

KW - Membrane Proteins

KW - Middle Aged

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Nitric Oxide Synthase Type II

KW - Prostaglandin-Endoperoxide Synthases

KW - Reverse Transcriptase Polymerase Chain Reaction

M3 - Article

C2 - 11556519

SN - 1023-3830

VL - 50

SP - 391

EP - 399

JO - Inflammation research : official journal of the European Histamine Research Society ... [et al.]

JF - Inflammation research : official journal of the European Histamine Research Society ... [et al.]

IS - 8

ER -

In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

Abstract

Keywords

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