Improving nefiracetam dissolution and solubility behavior using a cocrystallization approach

Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens

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    Abstract

    In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

    Original languageEnglish
    Article number653
    Pages (from-to)1-14
    Number of pages14
    JournalPharmaceutics
    Volume12
    Issue number7
    DOIs
    Publication statusPublished - Jul 2020

    Keywords

    • Cocrystals
    • Dissolution rate
    • Formulation
    • Nefiracetam
    • Solid state
    • Solubility
    • Stability

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