Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol, Koen Robeyns, Nikolay Tumanov, J. Wouters, Tom Leyssens

Research output: Contribution to journalArticle

Abstract

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

Original languageEnglish
Pages (from-to)3616-3622
Number of pages7
JournalJournal of Pharmaceutical Sciences
Volume108
Issue number11
Early online date24 Jul 2019
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

Nootropic Agents
Thermodynamics
Solubility
Pharmaceutical Preparations
nefiracetam

Keywords

  • dissolution
  • formulation
  • hydrate
  • nefiracetam
  • polymorph
  • solid state

Cite this

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Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms : A Potential Antidementia Drug. / Buol, Xavier; Robeyns, Koen; Tumanov, Nikolay; Wouters, J.; Leyssens, Tom.

In: Journal of Pharmaceutical Sciences, Vol. 108, No. 11, 01.11.2019, p. 3616-3622.

Research output: Contribution to journalArticle

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