Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol; Koen Robeyns; Nikolay Tumanov; J. Wouters; Tom Leyssens

doi:10.1016/j.xphs.2019.07.010

Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Xavier Buol, Koen Robeyns, Nikolay Tumanov, J. Wouters, Tom Leyssens

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

Original language	English
Pages (from-to)	3616-3622
Number of pages	7
Journal	Journal of Pharmaceutical Sciences
Volume	108
Issue number	11
Early online date	24 Jul 2019
DOIs	https://doi.org/10.1016/j.xphs.2019.07.010
Publication status	Published - 1 Nov 2019

Keywords

dissolution
formulation
hydrate
nefiracetam
polymorph
solid state

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10.1016/j.xphs.2019.07.010

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abstract = "In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.",

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AU - Robeyns, Koen

AU - Tumanov, Nikolay

AU - Wouters, J.

AU - Leyssens, Tom

PY - 2019/11/1

Y1 - 2019/11/1

N2 - In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

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KW - dissolution

KW - formulation

KW - hydrate

KW - nefiracetam

KW - polymorph

KW - solid state

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ER -

Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Abstract

Keywords

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Physical Chemistry and characterization(PC2)

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Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Abstract

Keywords

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Physical Chemistry and characterization(PC2)

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