TY - JOUR
T1 - HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: Role of MAP kinases
AU - Michiels, C.
AU - Minet, E.
AU - Michel, G.
AU - Mottet, D.
AU - Piret, J.-P.
AU - Raes, M.
PY - 2001
Y1 - 2001
N2 - HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
AB - HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0036139795&partnerID=8YFLogxK
U2 - 10.1080/15216540252774766
DO - 10.1080/15216540252774766
M3 - Article
AN - SCOPUS:0036139795
SN - 1521-6543
VL - 52
SP - 49
EP - 53
JO - IUBMB Life
JF - IUBMB Life
IS - 1-2
ER -