HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: Role of MAP kinases

C. Michiels, E. Minet, G. Michel, D. Mottet, J.-P. Piret, M. Raes

Research output: Contribution to journalArticle

Abstract

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalIUBMB Life
Volume52
Issue number1-2
DOIs
Publication statusPublished - 2001

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