TY - JOUR
T1 - HB-EGF, the growth factor that accelerates keratinocyte migration, but slows proliferation
AU - Poumay, Yves
AU - Lambert de Rouvroit, Catherine
PY - 2012
Y1 - 2012
N2 - Among epidermal growth factors, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is expressed unlike others, and produces unusual effects on keratinocytes. A new report illustrates the development of a motile phenotype characterized by signs of epithelial-mesenchymal transition, reduced proliferation, and altered expression of epidermal markers. We comment on differences between endogenous HB-EGF and recombinant factor, about opportune and inopportune situations of HB-EGF overexpression by epidermal keratinocytes, as well as about the consequences on epidermal tissues.
AB - Among epidermal growth factors, heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is expressed unlike others, and produces unusual effects on keratinocytes. A new report illustrates the development of a motile phenotype characterized by signs of epithelial-mesenchymal transition, reduced proliferation, and altered expression of epidermal markers. We comment on differences between endogenous HB-EGF and recombinant factor, about opportune and inopportune situations of HB-EGF overexpression by epidermal keratinocytes, as well as about the consequences on epidermal tissues.
U2 - 10.1038/jid.2012.225
DO - 10.1038/jid.2012.225
M3 - Article
C2 - 22895444
SN - 1523-1747
VL - 132
SP - 2129
EP - 2130
JO - The journal of investigative dermatology
JF - The journal of investigative dermatology
IS - 9
ER -