Genes coding for melanoma antigens recognised by cytolytic T lymphocytes

C De Smet, C Lurquin, E De Plaen, F Brasseur, H Zarour, O De Backer, P G Coulie, T Boon

Research output: Contribution to journalArticlepeer-review


It is now well established that human melanoma cells express antigens that are recognised by cytolytic T lymphocytes derived from the tumour-bearing patient. The molecular definition of these antigens is progressing at an accelerated pace. The currently characterised melanoma antigens can be classified into three categories: differentiation antigens, antigens encoded by genes that are specifically expressed in tumours, and antigens encoded by mutated genes. Several of these antigens are sufficiently tumour-specific to qualify them as candidate anti-cancer vaccines in melanoma patients.
Original languageEnglish
Pages (from-to)243-8
Number of pages6
JournalEye (London, England)
Volume11 ( Pt 2)
Publication statusPublished - 1997


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