Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

Kévin Buffet; Emilie Gillon; Michel Holler; Jean François Nierengarten; Anne Imberty; Stéphane Vincent

doi:10.1039/c5ob00689a

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

Kévin Buffet, Emilie Gillon, Michel Holler, Jean François Nierengarten, Anne Imberty, Stéphane Vincent

Unit of organic chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C₆₀(E)₁₂ bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

Original language	English
Pages (from-to)	6482-6492
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	23
DOIs	https://doi.org/10.1039/c5ob00689a
Publication status	Published - 21 Jun 2015

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10.1039/c5ob00689a

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abstract = "A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.",

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AU - Buffet, Kévin

AU - Gillon, Emilie

AU - Holler, Michel

AU - Nierengarten, Jean François

AU - Imberty, Anne

AU - Vincent, Stéphane

PY - 2015/6/21

Y1 - 2015/6/21

N2 - A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

AB - A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.

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ER -

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

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Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins

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