How can technology assessment methodologies be developed to move ethical questions to the forefront of enquiry? This methodological question was one of the key factors in an exercise in Responsible Research and Innovation carried out as part of SNIFFPHONE, a project on medical diagnostics. This paper discusses the methods used to apply Responsible Research and Innovation (RRI) in SNIFFPHONE, one of the European Commission's H2020 projects. In addition we will describe shortly implementation plan and first activities of RRI in another H2020 project, called BODEGA. The aim of the project is to build an expertise at the European level about human factors in future smart borders (e.g. ABC gates, video based risk analysis) in a way to enhance its efficiency without negative side effects.