Fragmentation of 4-sulfonylbicyclo[3.1.0]hexan-2-ones as the key step in the enantioselective synthesis of (1R)-cis-chrysanthemic acid involving desymmetrization of 3,3,6,6-tetramethylbicyclo[3.1.0]hexane-2,4-dione

A. Krief, A. Kremer

    Research output: Contribution to journalArticlepeer-review

    Abstract

    t-BuOK-HO (7.6:2.3) in THF or DMSO allows the efficient Grob-type fragmentation of 4-sulfonyl-bicyclo[3.1.0]hexan-2-ones which cannot be achieved by potassium hydroxide in DMSO as we originally described.
    Original languageEnglish
    Pages (from-to)607-610
    JournalSynlett
    Issue number4
    DOIs
    Publication statusPublished - 1 Mar 2007

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