Five-year follow-up of drug-eluting stents implantation vs minimally invasive direct coronary artery bypass for left anterior descending artery disease: A propensity score analysis

Pierre Yves Etienne, William D'hoore, Spiridon Papadatos, Yves Mairy, Gebrine El Khoury, Philippe Noirhomme, Claude Hanet, David Glineur

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The spread of drug-eluting stents (DES) has reduced the incidence of early restenosis following percutaneous coronary interventions (PCI). Meanwhile, development of minimally invasive coronary artery bypass surgery (MIDCAB) has offered a valuable alternative to conventional sternotomy with preservation of the benefit of the internal mammary artery use. Therefore, the revascularizationof the left anterior descending (LAD) artery is suitable for both techniques. However, few data with long-term comparison of these two techniques exist. METHODS: Prospective data were collected for 456 patients undergoing isolated LAD revascularization between 1997 and 2011. Two hundred and sixty patients were treated with MIDCAB and 196 with first-generation DES implantation. A propensity score model was created to adjust for 19 relevant confounding variables. Primary and secondary end-points were, respectively, 5-year survival and freedom from major adverse cerebro-cardiovascular events (MACCE). RESULTS: Both groups were similar in age, EuroSCORE and mean duration of follow-up. Five-year survival was similar after MIDCAB or DES (hazard ratio (HR): 0.95; P = 0.89). Freedom from MACCE was significantly in favour of the MIDCAB group (HR: 0.32, P < 0.0001), mainly triggered by high subsequent need for revascularization of the targeted vessel in the DES group (HR: 0.17, P < 0.0001). CONCLUSIONS: MIDCAB and DES implantation showed similar rates of survival but despite an expected lower rate of reintervention on the targeted vessel with DES use, a highly significant higher MACCE rate was observed in the PCI group at 5-year follow-up.

Original languageEnglish
Article numberezt137
Pages (from-to)884-890
Number of pages7
JournalEuropean Journal of Cardio-thoracic Surgery
Volume44
Issue number5
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

Keywords

  • Bypass
  • Coronary disease
  • Internal thoracic artery
  • Stent
  • Surgery

Fingerprint Dive into the research topics of 'Five-year follow-up of drug-eluting stents implantation vs minimally invasive direct coronary artery bypass for left anterior descending artery disease: A propensity score analysis'. Together they form a unique fingerprint.

  • Cite this