First and second generations of COX-2 selective inhibitors

Xavier de Leval; Fabien Julémont; Valérie Benoit; Michel Frederich; Bernard Pirotte; Jean-Michel Dogné

First and second generations of COX-2 selective inhibitors

Xavier de Leval, Fabien Julémont, Valérie Benoit, Michel Frederich, Bernard Pirotte, Jean-Michel Dogné

Research output: Contribution to journal › Article › peer-review

Abstract

The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

Original language	English
Pages (from-to)	597-601
Number of pages	5
Journal	Mini-reviews in medicinal chemistry
Volume	4
Issue number	6
Publication status	Published - Aug 2004

Keywords

Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Gastrointestinal Diseases
Humans
Isoenzymes
Isoxazoles
Lactones
Membrane Proteins
Prostaglandin-Endoperoxide Synthases
Pyrazoles
Pyridines
Sulfonamides
Sulfones

Cite this

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title = "First and second generations of COX-2 selective inhibitors",

abstract = "The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.",

keywords = "Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Gastrointestinal Diseases, Humans, Isoenzymes, Isoxazoles, Lactones, Membrane Proteins, Prostaglandin-Endoperoxide Synthases, Pyrazoles, Pyridines, Sulfonamides, Sulfones",

author = "{de Leval}, Xavier and Fabien Jul{\'e}mont and Val{\'e}rie Benoit and Michel Frederich and Bernard Pirotte and Jean-Michel Dogn{\'e}",

year = "2004",

month = aug,

language = "English",

volume = "4",

pages = "597--601",

journal = "Mini-reviews in medicinal chemistry",

issn = "1389-5575",

publisher = "Bentham Science Publishers B.V.",

number = "6",

}

TY - JOUR

T1 - First and second generations of COX-2 selective inhibitors

AU - de Leval, Xavier

AU - Julémont, Fabien

AU - Benoit, Valérie

AU - Frederich, Michel

AU - Pirotte, Bernard

AU - Dogné, Jean-Michel

PY - 2004/8

Y1 - 2004/8

N2 - The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

AB - The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

KW - Cyclooxygenase 2

KW - Cyclooxygenase 2 Inhibitors

KW - Cyclooxygenase Inhibitors

KW - Gastrointestinal Diseases

KW - Humans

KW - Isoenzymes

KW - Isoxazoles

KW - Lactones

KW - Membrane Proteins

KW - Prostaglandin-Endoperoxide Synthases

KW - Pyrazoles

KW - Pyridines

KW - Sulfonamides

KW - Sulfones

M3 - Article

C2 - 15279593

SN - 1389-5575

VL - 4

SP - 597

EP - 601

JO - Mini-reviews in medicinal chemistry

JF - Mini-reviews in medicinal chemistry

IS - 6

ER -

First and second generations of COX-2 selective inhibitors

Abstract

Keywords

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