First and second generations of COX-2 selective inhibitors

Xavier de Leval, Fabien Julémont, Valérie Benoit, Michel Frederich, Bernard Pirotte, Jean-Michel Dogné

Research output: Contribution to journalArticlepeer-review

Abstract

The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalMini-reviews in medicinal chemistry
Volume4
Issue number6
Publication statusPublished - Aug 2004

Keywords

  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Gastrointestinal Diseases
  • Humans
  • Isoenzymes
  • Isoxazoles
  • Lactones
  • Membrane Proteins
  • Prostaglandin-Endoperoxide Synthases
  • Pyrazoles
  • Pyridines
  • Sulfonamides
  • Sulfones

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