Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.
Schiavo, L., Jeanmart, L., Lanners, S., Chopin, S., & Hanquet, G. (2017). FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process. New Journal of Chemistry, 41(4), 1421-1424. [10.1039/C6NJ03439J]. https://doi.org/10.1039/C6NJ03439J