FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Lucie Schiavo, Loïc Jeanmart, Steve Lanners, Sabine Chopin, Gilles Hanquet

Research output: Contribution to journalArticle

Abstract

Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.
Original languageEnglish
Article number10.1039/C6NJ03439J
Pages (from-to)1421-1424
Number of pages4
JournalNew Journal of Chemistry
Volume41
Issue number4
DOIs
Publication statusPublished - 2017

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Acetals
Acetaldehyde
Aldehydes
Silica Gel
Silica gel
Ketones
Byproducts
Evaporation
Iron

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FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process. / Schiavo, Lucie; Jeanmart, Loïc; Lanners, Steve; Chopin, Sabine; Hanquet, Gilles.

In: New Journal of Chemistry, Vol. 41, No. 4, 10.1039/C6NJ03439J, 2017, p. 1421-1424.

Research output: Contribution to journalArticle

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AU - Hanquet, Gilles

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