FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Lucie Schiavo, Loïc Jeanmart, Steve Lanners, Sabine Chopin, Gilles Hanquet

Research output: Contribution to journalArticle


Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.
Original languageEnglish
Article number10.1039/C6NJ03439J
Pages (from-to)1421-1424
Number of pages4
JournalNew Journal of Chemistry
Issue number4
Publication statusPublished - 2017


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