FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Lucie Schiavo; Loïc Jeanmart; Steve Lanners; Sabine Chopin; Gilles Hanquet

doi:10.1039/c6nj03439j

FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Lucie Schiavo, Loïc Jeanmart, Steve Lanners, Sabine Chopin, Gilles Hanquet

Research output: Contribution to journal › Article › peer-review

Abstract

Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.

Original language	English
Article number	10.1039/C6NJ03439J
Pages (from-to)	1421-1424
Number of pages	4
Journal	New Journal of Chemistry
Volume	41
Issue number	4
DOIs	https://doi.org/10.1039/c6nj03439j
Publication status	Published - 2017

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10.1039/c6nj03439j

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AU - Chopin, Sabine

AU - Hanquet, Gilles

PY - 2017

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AB - Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(III)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.

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FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

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FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

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