Fatty acid amide hydrolase: from characterization to therapeutics

Geoffray Labar, Catherine Michaux

Research output: Contribution to journalArticlepeer-review


Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.
Original languageEnglish
Pages (from-to)1882-1902
Number of pages21
JournalChemistry & biodiversity
Issue number8
Publication statusPublished - 2007


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