Fate of SiC and TiC nanoparticle dispersions in human reconstituted gastric fluid

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Abstract

In this work, we explore the evolution of the physicochemical properties of silicon carbide and titanium carbide nanoparticles in human reconstituted gastric fluid in the conditions of a normal digestion. The nanoparticles were pre-dispersed in water or in a pluronic F108 solution. Key parameters as the particle size distribution and the surface composition of the nanoparticles were monitored. The results show that the modifications produced during the simulated digestion are dispersion medium dependent. Carbon and nitrogen were found to be adsorbed on the surface of both nanoparticles in a dispersion medium dependent way. The reported results contribute to understand the biological impact of these nanoparticles in biofluids and biocompatible media.
Original languageEnglish
Pages (from-to)243-255
Number of pages13
JournalInternational Journal of Nano and Biomaterials
Volume4
Issue number3-4
DOIs
Publication statusPublished - 2012

Keywords

  • SiC nanoparticles
  • TiC nanoparticles
  • human reconstituted gastric fluid
  • particle size distribution
  • surface composition

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