@article{dece0f420751472a91ff1782224bdfec,
title = "Fast, asymmetric and nonhomogeneous clearance of SiC nanoaerosol assessed by micro-particle-induced x-ray emission",
abstract = "Aim: To study the biopersistence of a silicon carbide (SiC) nanoaerosol in rat lungs, as time-dependent clearance and spatial distribution. Materials & methods: Sprague-Dawley rats were exposed 6 h/day during 5 days to a SiC nanoaerosol at 4.91 mg SiC/l. SiC biopersistence in rat lungs sections was assessed over 28 days by micro-particle-induced x-ray emission (μPIXE) as 2D maps and by particle-induced x-ray emission (PIXE) for whole-lung quantification. 2D maps were analyzed for SiC spatial distribution as skewness and kurtosis. Results: Half-Time clearance was 10.9 ± 0.9 days, agreeing with PIXE measurements. Spatialtemporal analysis of SiC indicated decreased symmetry and homogeneity. Conclusion: Fast SiC clearance points that current nanoaerosol exposuremay not be enough to trigger lung overload. Spatial distribution shows an asymmetric and nonhomogeneous SiC clearance.",
keywords = "Biopersistence, Particle-induced x-ray emission, Rat lungs, SiC nanoparticles, μPIXE",
author = "Omar Lozano and Colaux, {Julien L.} and Julie Laloy and L{\"u}tfiye Alpan and Dogn{\'e}, {Jean Michel} and Stephane Lucas",
note = "Funding Information: This work was supported by The European Community{\textquoteright}s Seventh Framework Programme (FP7/2007–2013; grant numbers 310584 [NANoREG – A common European approach to the regulatory testing of nanomaterials] and 227012 [Integrating activity SPIRIT – Support of Public and Industrial Research Using Ion Beam Technology]); and from Service Public de Wallonie (SPW) – Direction g{\'e}n{\'e}rale op{\'e}rationnelle – Economie, Emploi et Recherche (DGO6), D{\'e}partement des Programmes de Recherche (grant numbers 516252 [Nanotoxico Project, SPW/FUNDP research convention] and 1317938 [Compl{\'e}ment FP7]). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2018",
month = jan,
day = "1",
doi = "10.2217/nnm-2017-0245",
language = "English",
volume = "13",
pages = "145--155",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine Ltd.",
number = "2",
}