Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Adeline Wannez; Bérangère Devalet; Bernard Chatelain; Christian Chatelain; Jean-Michel Dogné; François Mullier

doi:10.1016/j.tmrv.2019.02.002

Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Adeline Wannez, Bérangère Devalet, Bernard Chatelain, Christian Chatelain, Jean-Michel Dogné, François Mullier

Research output: Contribution to journal › Review article › peer-review

Abstract

Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Transfusion Medicine Reviews
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.tmrv.2019.02.002
Publication status	Published - 1 Apr 2019

Funding

The authors thank Dr. Ruth Murray for language editing. This work was supported by F.R.S.-FNRS-Télévie Belgium (grant N° 7652916F).

Funders	Funder number
F.R.S.-FNRS-Télévie Belgium	7652916F

Keywords

Blood transfusions
Extracellular vesicles
Microparticles
Red blood cell concentrate

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10.1016/j.tmrv.2019.02.002

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title = "Extracellular Vesicles in Red Blood Cell Concentrates: An Overview",

abstract = "Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.",

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AU - Wannez, Adeline

AU - Devalet, Bérangère

AU - Chatelain, Bernard

AU - Chatelain, Christian

AU - Dogné, Jean-Michel

AU - Mullier, François

PY - 2019/4/1

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AB - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

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M3 - Review article

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Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

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