Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Research output: Contribution to journalReview article

Abstract

Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalTransfusion Medicine Reviews
Volume33
Issue number2
DOIs
Publication statusPublished - 1 Apr 2019

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Blood
Erythrocytes
Cells
Assays
Thrombin
Quality control
Quality Control
Extracellular Vesicles
Tissue Donors

Keywords

  • Blood transfusions
  • Extracellular vesicles
  • Microparticles
  • Red blood cell concentrate

Cite this

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title = "Extracellular Vesicles in Red Blood Cell Concentrates: An Overview",
abstract = "Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.",
keywords = "Blood transfusions, Extracellular vesicles, Microparticles, Red blood cell concentrate",
author = "Adeline Wannez and B{\'e}rang{\`e}re Devalet and Bernard Chatelain and Christian Chatelain and Dogn{\'e}, {Jean Michel} and Fran{\cc}ois Mullier",
note = "Copyright {\circledC} 2019 Elsevier Inc. All rights reserved.",
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AU - Wannez, Adeline

AU - Devalet, Bérangère

AU - Chatelain, Bernard

AU - Chatelain, Christian

AU - Dogné, Jean Michel

AU - Mullier, François

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N2 - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

AB - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

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