Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Adeline Wannez; Bérangère Devalet; Bernard Chatelain; Christian Chatelain; Jean-Michel Dogné; François Mullier

doi:10.1016/j.tmrv.2019.02.002

Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Adeline Wannez, Bérangère Devalet, Bernard Chatelain, Christian Chatelain, Jean-Michel Dogné, François Mullier

Research output: Contribution to journal › Review article › peer-review

Abstract

Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Transfusion Medicine Reviews
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.tmrv.2019.02.002
Publication status	Published - 1 Apr 2019

Keywords

Blood transfusions
Extracellular vesicles
Microparticles
Red blood cell concentrate

Access to Document

10.1016/j.tmrv.2019.02.002

Cite this

@article{9588e7a9fd264884bd5cf31ee3256b82,

title = "Extracellular Vesicles in Red Blood Cell Concentrates: An Overview",

abstract = "Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.",

keywords = "Blood transfusions, Extracellular vesicles, Microparticles, Red blood cell concentrate",

author = "Adeline Wannez and B{\'e}rang{\`e}re Devalet and Bernard Chatelain and Christian Chatelain and Jean-Michel Dogn{\'e} and Fran{\c c}ois Mullier",

year = "2019",

month = apr,

day = "1",

doi = "10.1016/j.tmrv.2019.02.002",

language = "English",

volume = "33",

pages = "125--130",

journal = "Transfusion Medicine Reviews",

issn = "0887-7963",

publisher = "W.B. Saunders",

number = "2",

}

TY - JOUR

T1 - Extracellular Vesicles in Red Blood Cell Concentrates

T2 - An Overview

AU - Wannez, Adeline

AU - Devalet, Bérangère

AU - Chatelain, Bernard

AU - Chatelain, Christian

AU - Dogné, Jean-Michel

AU - Mullier, François

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

AB - Red blood cell (RBC) concentrates may be stored for up to 42 days before transfusion to a patient. During storage extracellular vesicles (EVs) develop and can be detected in significant amounts in RBC concentrates. The concentration of EVs is affected by component preparation methods, storage solutions, and inter-donor variation. Laboratory investigations have focused on the effect of EVs on in vitro assays of thrombin generation and immune responses. Assays for EVs in RBC concentrates are not standardized. The aims of this review are to describe the factors that determine the presence of erythrocyte-EVs in RBC concentrates, the current techniques used to characterize them, and the potential role of EV analysis as a quality control maker for RBC storage.

KW - Blood transfusions

KW - Extracellular vesicles

KW - Microparticles

KW - Red blood cell concentrate

UR - http://www.scopus.com/inward/record.url?scp=85063208767&partnerID=8YFLogxK

U2 - 10.1016/j.tmrv.2019.02.002

DO - 10.1016/j.tmrv.2019.02.002

M3 - Review article

C2 - 30910256

AN - SCOPUS:85063208767

SN - 0887-7963

VL - 33

SP - 125

EP - 130

JO - Transfusion Medicine Reviews

JF - Transfusion Medicine Reviews

IS - 2

ER -

Extracellular Vesicles in Red Blood Cell Concentrates: An Overview

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this