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Abstract
Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed.
Original language | English |
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Title of host publication | Dermatophytes and Dermatophytoses |
Editors | Jean-Philippe Bouchara, Pietro Nenoff, Aditya K. Gupta, Vishnu Chaturvedi |
Place of Publication | Cham, Switzerland |
Publisher | Springer |
Pages | 135-160 |
Number of pages | 26 |
ISBN (Electronic) | 978-3-030-67421-2 |
ISBN (Print) | 978-3-030-67420-5 |
DOIs | |
Publication status | Published - 8 Jun 2021 |
Keywords
- Adhesion
- Antifungal efficacy
- Dermatophytosis
- Experimental models
- Host responses
- Invasion
- Microsporum canis
- Reconstructed human epidermis
- Skin equivalents
- Trichophyton rubrum
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Student theses
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Pathogénie d’une dermatophytose (Trichophyton rubrum) sur épiderme humain reconstruit
Author: Faway, É., 7 Mar 2018Supervisor: Lambert De Rouvroit, C. (Co-Supervisor), Poumay, Y. (Supervisor), De Bolle, X. (President), Del-Marmol, V. (External person) (Jury), Jonca, N. (External person) (Jury), Mignon, B. R. (External person) (Jury) & Monod, M. (External person) (Jury)
Student thesis: Doc types › Doctor of Biomedical and Pharmaceutical Sciences
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