Experimental models of dermatophytosis

Émilie Faway; Marc Thiry; Bernard Mignon; Yves Poumay

doi:10.1007/978-3-030-67421-2_7

Experimental models of dermatophytosis

Émilie Faway, Marc Thiry, Bernard Mignon, Yves Poumay

Research output: Contribution in Book/Catalog/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed.

Original language	English
Title of host publication	Dermatophytes and Dermatophytoses
Editors	Jean-Philippe Bouchara, Pietro Nenoff, Aditya K. Gupta, Vishnu Chaturvedi
Place of Publication	Cham, Switzerland
Publisher	Springer
Pages	135-160
Number of pages	26
ISBN (Electronic)	978-3-030-67421-2
ISBN (Print)	978-3-030-67420-5
DOIs	https://doi.org/10.1007/978-3-030-67421-2_7
Publication status	Published - 8 Jun 2021

Keywords

Adhesion
Antifungal efficacy
Dermatophytosis
Experimental models
Host responses
Invasion
Microsporum canis
Reconstructed human epidermis
Skin equivalents
Trichophyton rubrum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-67421-2_7

Cite this

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abstract = "Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed. ",

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Experimental models of dermatophytosis. / Faway, Émilie; Thiry, Marc; Mignon, Bernard et al.
Dermatophytes and Dermatophytoses. ed. / Jean-Philippe Bouchara; Pietro Nenoff; Aditya K. Gupta; Vishnu Chaturvedi. Cham, Switzerland: Springer, 2021. p. 135-160.

Research output: Contribution in Book/Catalog/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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T1 - Experimental models of dermatophytosis

AU - Faway, Émilie

AU - Thiry, Marc

AU - Mignon, Bernard

AU - Poumay, Yves

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021.

PY - 2021/6/8

Y1 - 2021/6/8

N2 - Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed.

AB - Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed.

KW - Adhesion

KW - Antifungal efficacy

KW - Dermatophytosis

KW - Experimental models

KW - Host responses

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KW - Microsporum canis

KW - Reconstructed human epidermis

KW - Skin equivalents

KW - Trichophyton rubrum

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SP - 135

EP - 160

BT - Dermatophytes and Dermatophytoses

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A2 - Nenoff, Pietro

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A2 - Chaturvedi, Vishnu

PB - Springer

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Experimental models of dermatophytosis

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Embargoed Document

Fingerprint

MycEpi: Développement et validation d’un modèle multivalent de dermatophytose in vitro, en vue de son exploitation analytique, diagnostique et pharmacologique

Pathogénie d’une dermatophytose (Trichophyton rubrum) sur épiderme humain reconstruit

Cite this

Experimental models of dermatophytosis

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Embargoed Document

Fingerprint

Projects

MycEpi: Développement et validation d’un modèle multivalent de dermatophytose in vitro, en vue de son exploitation analytique, diagnostique et pharmacologique

Student theses

Pathogénie d’une dermatophytose (Trichophyton rubrum) sur épiderme humain reconstruit

Cite this