Experimental models of dermatophytosis

Émilie Faway, Marc Thiry, Bernard Mignon, Yves Poumay

Research output: Contribution in Book/Catalog/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments. Several experimental models have then been developed in order to improve knowledge about this infection and to design new therapeutic strategies. This chapter presents the variety of dermatophytosis experimental models and their contribution in the understanding of mechanisms used by dermatophytes to adhere and to invade the host tissue. Their support to study the establishment of effective antifungal defenses by the host is also summarized. The usefulness of these models for testing the efficacy of antifungal compounds is finally discussed.
Original languageEnglish
Title of host publicationDermatophytes and Dermatophytoses
EditorsJean-Philippe Bouchara, Pietro Nenoff, Aditya K. Gupta, Vishnu Chaturvedi
Place of PublicationCham, Switzerland
PublisherSpringer
Pages135-160
Number of pages26
ISBN (Electronic)978-3-030-67421-2
ISBN (Print)978-3-030-67420-5
DOIs
Publication statusPublished - 2021

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