Ethoxycarbonyl functionalized Tröger's base alongside its congener dihydroquinazoline: A trick with crystallization

Vitaly Kovalenko, Nikolay Tumanov, Kiryl Vasiutovich, Tom Leyssens

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Abstract

The synthesis of ethoxycarbonyl functionalized Tröger's base is accompanied by the formation of a considerable amount of a 3,4-dihydroquinazoline by-product. We found that both compounds can be readily isolated from reaction mixture on a preparative scale by standard crystallization from appropriate solvents.

Original languageEnglish
Article number100339
JournalChemical Data Collections
Volume25
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Crystallization
  • Dihydroquinazolines
  • Reaction intermediate
  • Separation
  • Tröger's base

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