Epidermal reference genes at the forefront of data interpretation

Abdallah Mound, Jérémy Malaisse, Évelyne De Vuyst, Aurélie Hayez, Catherine Lambert de Rouvroit, Mark R Pittelkow, Yves Poumay

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Abstract

The characterization of gene expression, its identification and its measurement, is essential for understanding the somewhat unique fate of keratinocytes, their normal functions, but also the behavior of this cell type in skin diseases. Normal keratinocytes first proliferate under strict control before being committed towards a progressive program of cell death as differentiated, highly resistant, squamous structures during the keratinization process. Keratinization is intended to create the epidermal barrier for terrestrial vertebrates. During terminal differentiation, keratinocytes fire up certain genes while down-regulating others and maintaining almost constant a third category of genes, those required in any circumstance to respond to usual cellular needs (e.g. synthesis of macromolecules, availability of energy, movement of organelles, etc.). This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)738-739
Number of pages2
JournalExperimental dermatology
Volume24
Issue number10
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • Epidermis
  • Gene expression
  • Keratinocyte
  • Reference gene

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