The characterization of gene expression, its identification and its measurement, is essential for understanding the somewhat unique fate of keratinocytes, their normal functions, but also the behavior of this cell type in skin diseases. Normal keratinocytes first proliferate under strict control before being committed towards a progressive program of cell death as differentiated, highly resistant, squamous structures during the keratinization process. Keratinization is intended to create the epidermal barrier for terrestrial vertebrates. During terminal differentiation, keratinocytes fire up certain genes while down-regulating others and maintaining almost constant a third category of genes, those required in any circumstance to respond to usual cellular needs (e.g. synthesis of macromolecules, availability of energy, movement of organelles, etc.). This article is protected by copyright. All rights reserved.
|Number of pages||2|
|Publication status||Published - 1 Oct 2015|
- Gene expression
- Reference gene
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Barrier alterations in a reconstructed epidermis as a model for atopic dermatitisAuthor: De Vuyst, E., 20 Dec 2016
Supervisor: Poumay, Y. (Supervisor), Lambert De Rouvroit, C. (Co-Supervisor), Michiels, C. (President), Gillet, J. (Jury), Brandner, J. (External person) (Jury), Salmon, M. (External person) (Jury) & Nikkels, A. F. (External person) (Jury)
Student thesis: Doc types › Doctor of Biomedical and Pharmaceutical Sciences