Effects of vitamin D in the elderly population: Current status and perspectives

Olivier Bruyère, Etienne Cavalier, Jean Claude Souberbielle, Heike A. Bischoff-Ferrari, Charlotte Beaudart, Fanny Buckinx, Jean Yves Reginster, René Rizzoli

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Abstract

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case-control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated.

Original languageEnglish
Article number32
JournalArchives of Public Health
Volume72
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

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