Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

X de Leval; J M Dogné; P Neven; A Labasse; J Delarge; J Y Reginster; Y Henrotin

Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

X de Leval, J M Dogné, P Neven, A Labasse, J Delarge, J Y Reginster, Y Henrotin

Research output: Contribution to journal › Article › peer-review

Abstract

Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.

Original language	English
Pages (from-to)	89-90
Number of pages	2
Journal	Journal de Pharmacie de Belgique
Volume	54
Issue number	3
Publication status	Published - 1999

Keywords

Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Indomethacin
Isoenzymes
Prostaglandin-Endoperoxide Synthases
Substrate Specificity
Sulfonamides

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title = "Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study",

abstract = "Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.",

keywords = "Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Indomethacin, Isoenzymes, Prostaglandin-Endoperoxide Synthases, Substrate Specificity, Sulfonamides",

author = "{de Leval}, X and Dogn{\'e}, {J M} and P Neven and A Labasse and J Delarge and Reginster, {J Y} and Y Henrotin",

year = "1999",

language = "English",

volume = "54",

pages = "89--90",

journal = "Journal de Pharmacie de Belgique",

issn = "0047-2166",

publisher = "APB Algemene Pharmaceutische Bond",

number = "3",

}

TY - JOUR

T1 - Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

AU - de Leval, X

AU - Dogné, J M

AU - Neven, P

AU - Labasse, A

AU - Delarge, J

AU - Reginster, J Y

AU - Henrotin, Y

PY - 1999

Y1 - 1999

N2 - Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.

AB - Evidence of the existence of two forms of cyclooxygenases and the clinical relevance of COX-2 inhibition led to the development of COX-2 selective NSAIDs. In order to evaluate this selectivity, we have developed and validated an enzymatic method. The precision and reproducibility of the assay were determined and COX-2 selectivity examined using nimesulide and indometacin.

KW - Cyclooxygenase 1

KW - Cyclooxygenase 2

KW - Cyclooxygenase 2 Inhibitors

KW - Cyclooxygenase Inhibitors

KW - Indomethacin

KW - Isoenzymes

KW - Prostaglandin-Endoperoxide Synthases

KW - Substrate Specificity

KW - Sulfonamides

M3 - Article

C2 - 10431478

SN - 0047-2166

VL - 54

SP - 89

EP - 90

JO - Journal de Pharmacie de Belgique

JF - Journal de Pharmacie de Belgique

IS - 3

ER -

Effects of nimesulide and indometacin on COX-1 and COX-2: a comparative study

Abstract

Keywords

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