Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.
|Number of pages||5|
|Journal||Annals of the New York academy of sciences|
|Publication status||Published - 2002|
- DNA microarray
- Endothelial dysfunction