Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro

A. Tacheny; Sofia Dos Santos Mendes; A. C. Huet; M. Van Steenbrugge; C. Michiels; P. Holvoet; Martine Raes

Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro

A. Tacheny, Sofia Dos Santos Mendes, A. C. Huet, M. Van Steenbrugge, C. Michiels, P. Holvoet, Martine Raes

Laboratory of Cellular Biochemistry and Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.

Original language	English
Pages (from-to)	550-554
Number of pages	5
Journal	Annals of the New York academy of sciences
Volume	973
Publication status	Published - 2002

Keywords

Atherosclerosis
DNA microarray
Endothelial dysfunction
Hyperhomocysteinemia

Cite this

@article{0a22f77ee5784c26a3a5d3ece260f74c,

title = "Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro",

abstract = "Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.",

keywords = "Atherosclerosis, DNA microarray, Endothelial dysfunction, Hyperhomocysteinemia",

author = "A. Tacheny and {Dos Santos Mendes}, Sofia and Huet, {A. C.} and {Van Steenbrugge}, M. and C. Michiels and P. Holvoet and Martine Raes",

year = "2002",

language = "English",

volume = "973",

pages = "550--554",

journal = "Annals of the New York academy of sciences",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro

AU - Tacheny, A.

AU - Dos Santos Mendes, Sofia

AU - Huet, A. C.

AU - Van Steenbrugge, M.

AU - Michiels, C.

AU - Holvoet, P.

AU - Raes, Martine

PY - 2002

Y1 - 2002

N2 - Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.

AB - Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a proto-type DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-α was used as a positive control.

KW - Atherosclerosis

KW - DNA microarray

KW - Endothelial dysfunction

KW - Hyperhomocysteinemia

UR - http://www.scopus.com/inward/record.url?scp=0036962032&partnerID=8YFLogxK

M3 - Article

C2 - 12485927

VL - 973

SP - 550

EP - 554

JO - Annals of the New York academy of sciences

JF - Annals of the New York academy of sciences

ER -

Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro

Abstract

Keywords

Other files and links

Fingerprint

Cite this