Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock

B Lambermont; A Ghuysen; J-M Dogné; P Kolh; V Tchana-Sato; P Morimont; P Benoit; P Gérard; B Masereel; V D'Orio

doi:10.1076/apab.111.3.224.23457

Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock

B Lambermont, A Ghuysen, J-M Dogné, P Kolh, V Tchana-Sato, P Morimont, P Benoit, P Gérard, B Masereel, V D'Orio

Research output: Contribution to journal › Article › peer-review

Abstract

Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p

Original language	English
Pages (from-to)	224-31
Number of pages	8
Journal	Archives of Physiology and Biochemistry
Volume	111
Issue number	3
DOIs	https://doi.org/10.1076/apab.111.3.224.23457
Publication status	Published - Jul 2003

Keywords

Animals
Arachidonic Acid
Blood Pressure
Cardiac Output
Female
Heart Rate
Male
Oxygen Consumption
Partial Pressure
Platelet Aggregation
Pulmonary Artery
Pulmonary Circulation
Shock, Septic
Sulfonylurea Compounds
Swine
Thromboxane A2

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10.1076/apab.111.3.224.23457

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title = "Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock",

abstract = "Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p ",

keywords = "Animals, Arachidonic Acid, Blood Pressure, Cardiac Output, Female, Heart Rate, Male, Oxygen Consumption, Partial Pressure, Platelet Aggregation, Pulmonary Artery, Pulmonary Circulation, Shock, Septic, Sulfonylurea Compounds, Swine, Thromboxane A2",

author = "B Lambermont and A Ghuysen and J-M Dogn{\'e} and P Kolh and V Tchana-Sato and P Morimont and P Benoit and P G{\'e}rard and B Masereel and V D'Orio",

year = "2003",

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doi = "10.1076/apab.111.3.224.23457",

language = "English",

volume = "111",

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T1 - Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock

AU - Lambermont, B

AU - Ghuysen, A

AU - Dogné, J-M

AU - Kolh, P

AU - Tchana-Sato, V

AU - Morimont, P

AU - Benoit, P

AU - Gérard, P

AU - Masereel, B

AU - D'Orio, V

PY - 2003/7

Y1 - 2003/7

N2 - Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p

AB - Thromboxane A2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 +/- 1.8 (T0) to 42 +/- 2.3 mmHg (T60) (p

KW - Animals

KW - Arachidonic Acid

KW - Blood Pressure

KW - Cardiac Output

KW - Female

KW - Heart Rate

KW - Male

KW - Oxygen Consumption

KW - Partial Pressure

KW - Platelet Aggregation

KW - Pulmonary Artery

KW - Pulmonary Circulation

KW - Shock, Septic

KW - Sulfonylurea Compounds

KW - Swine

KW - Thromboxane A2

U2 - 10.1076/apab.111.3.224.23457

DO - 10.1076/apab.111.3.224.23457

M3 - Article

C2 - 14972744

SN - 1381-3455

VL - 111

SP - 224

EP - 231

JO - Archives of Physiology and Biochemistry

JF - Archives of Physiology and Biochemistry

IS - 3

ER -

Effects of BM-573, a novel thromboxane A2 inhibitor, on pulmonary hemodynamics in endotoxic shock

Abstract

Keywords

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